Safety
The deepest defensive player, the last line of defense against long passes.
The safety plays farther from the line of scrimmage than any other defender, with the main job of preventing deep passes and back-breaking touchdowns. From that vantage point, they see the whole field and often call out defensive adjustments to the rest of the unit.
There are generally two types: the free safety, faster and geared toward pass coverage, and the strong safety, more physical and involved in stopping runs near the line of scrimmage. Modern teams increasingly use versatile safeties who can play either role depending on the situation.
One possible mix-up: "safety" is also the name of a scoring play worth two points, awarded when the offense is tackled in its own end zone. The two meanings are completely unrelated despite sharing the word.
Secondary
The defensive backs — cornerbacks and safeties — responsible for pass coverage.
The secondary is the collective name for the cornerbacks and safeties, the players positioned furthest from the line of scrimmage. Their main job is pass coverage — stopping opposing receivers from catching the ball, especially on longer routes.
Unlike the front seven (the defensive line and linebackers), who deal primarily with stopping the run and pressuring the quarterback, the secondary takes center stage on passing plays. A weak secondary can turn an average passing offense into a devastating one, no matter how good the rest of the defense is.
Commentators often talk about the secondary getting "beat" — a moment when coverage breaks down and a receiver comes open for a long completion.
Spread
The number of points a team is expected to win or lose by, according to the betting market.
The spread (or "line") is the standard way the market expresses how balanced a game is considered. If a team is "favored by 4.5 points," it means they're expected to win by more than 4.5 points to be considered the winner from that line's perspective.
The spread isn't a prediction of the final score — it's a tool for balancing interest on both sides, set by sportsbooks based on statistical analysis and where money is being wagered. That's why it shifts constantly; for example, a significant injury announced a few days before a game can move the line by several points.
For a reader new to American football, the simplest way to understand the spread is as a quick indicator of how close a game is considered by experts: the bigger the line, the clearer the gap in level between the two teams is thought to be.